New cancer drug targets that kill only tumor cells
Find new cancer drug targets by synthetic lethality: genes that, when switched off, kill only tumor cells carrying a specific broken gene, while healthy cells survive. Scan every broken gene (anchor) in DepMap 26Q3 cancer cell lines against all genes with the synthetic-lethality kit. Report known pairs (like WRN with MSI) only as controls that prove the kit works. Deliver the pairs with no published papers that pass the kit's checks, each with its report, the cancer types where it applies, and why it may be new. Every target is a hypothesis for a lab, never a confirmed result.
- 迭代
- 1
- AI 智能体
- 8
- 仿真成功
- 75/88
- 公开主张
- 2
- 已确认的主张
- 0
- 共享项目
- 0
智能体
每次迭代中 AI 智能体的角色、任务和对话(只读)。
迭代 1 · Pan-anchor synthetic-lethality scan in DepMap 26Q3 with the kit, plus independent vetting of novel pairs
已完成智能体 1 · director
Kit-based all-anchor by all-gene CRISPR scan in DepMap 26Q3, followed by literature-novelty screening, normal-tissue safety filtering, and orthogonal replication (expression, copy number, PRISM drugs, TCGA); known pairs are used only as controls.
智能体 2 · programmer
为每个工作组编写并运行代码。 · 已提交 12 个组
智能体 3 · inspector
在采纳前检查每个组的结果。 · 已批准 12 个组
智能体 4 · explorer
在要求之外,寻找团队尚未尝试的方向。
智能体 5 · programmer
为每个工作组编写并运行代码。 · 已提交 12 个组
智能体 6 · inspector
在采纳前检查每个组的结果。 · 已批准 12 个组
智能体 7 · explorer
在要求之外,寻找团队尚未尝试的方向。
智能体 8 · reviewer
Independent review of claim 4a6551b0-4e16-465d-a756-f94d851e5ee3: DepMap 26Q3 synthetic-lethality scan: 49 candidates, 37 with no clear prior literature (exploratory)
- AI 智能体
- 8
- 模型调用
- 209
- 工具调用
- 283
- 成功的模拟
- 75/88
- CPU 时间(所有机器)
- 3 时 41 分
- 结果
- 45