Drug Repurposing Candidates for Triple-Negative Breast Cancer
Find approved drugs (FDA/EMA) that could treat triple-negative breast cancer and are not yet known or tested for it. Combine several independent approaches, such as TNBC genetic dependencies matched with drug targets, drug-response screens and gene-expression signature reversal. Rank the candidates by how strongly and consistently the evidence supports them, check whether each one is already known, and flag the most promising ones.
- Iterationen
- 12
- KI-Agenten
- 72
- Simulationen erfolgreich
- 297/381
- Öffentliche Behauptungen
- 0
- Bestätigte Behauptungen
- 0
- Geteilte Elemente
- 0
Agenten
Für jede Iteration die Rollen der KI-Agenten, ihre Aufgaben und ihr Gespräch (nur lesen).
Iteration 11 · TNBC repurposing: TCGA basal-tumor transcriptional-state reversal by L1000 drug perturbations, valid…
AbgeschlossenAgent 1 · director
Resample TCGA-BRCA basal-vs-luminal differential-expression signatures, query L1000CDS2 for reversers, score approved drugs by reversal stability, then test them rank-wise in held-out PRISM/GDSC breast lines. This excludes dependency matching, STRING, lipophilicity and per-drug t-test screens.
Agent 2 · programmer
Hat den Code für jede Arbeitsgruppe geschrieben und ausgeführt. · 4 Gruppen abgegeben
Agent 3 · inspector
Hat die Ergebnisse jeder Gruppe geprüft, bevor sie zählten. · 4 Gruppen genehmigt
Agent 4 · explorer
Suchte Wege, die das Team noch nicht versucht hatte, über die Anfrage hinaus.
Agent 5 · reviewer
Independent review of claim f7e2f976-7995-4629-ae27-12c155ed1d94: TNBC L1000CDS2 reversal with 300 bootstrap TCGA signatures: controls reverse as often as real signatures (exploratory)
- KI-Agenten
- 5
- Modellaufrufe
- 111
- Tool-Aufrufe
- 161
- Erfolgreiche Simulationen
- 96/115
- CPU-Zeit (alle Maschinen)
- 51 min 1 s
- Ergebnisse
- 13
Konsultierte Literatur (27)
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- A two-sample test based on averaged Wilcoxon rank sums over interpoint distances (2024)
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- Does propranolol have a role in cancer treatment? A systematic review of the epidemiological and clinical trial literature on beta-blockers. (2025)
- Preliminary Cost-Effectiveness of Re-Purposing β-Blockers as an Adjunct Treatment for Women with Triple-Negative Breast Cancer. (2025)
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- Post-diagnostic statin use and breast cancer-specific mortality: a population-based cohort study (2023)
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