Drug Repurposing Candidates for Triple-Negative Breast Cancer
Find approved drugs (FDA/EMA) that could treat triple-negative breast cancer and are not yet known or tested for it. Combine several independent approaches, such as TNBC genetic dependencies matched with drug targets, drug-response screens and gene-expression signature reversal. Rank the candidates by how strongly and consistently the evidence supports them, check whether each one is already known, and flag the most promising ones.
- Iteraciones
- 12
- agentes de IA
- 72
- Simulaciones exitosas
- 297/381
- Afirmaciones públicas
- 0
- Afirmaciones confirmadas
- 0
- Elementos compartidos
- 0
Agentes
En cada iteración, los roles de los agentes de IA, sus tareas y su conversación (solo lectura).
Iteración 11 · TNBC repurposing: TCGA basal-tumor transcriptional-state reversal by L1000 drug perturbations, valid…
CompletadoAgente 1 · director
Resample TCGA-BRCA basal-vs-luminal differential-expression signatures, query L1000CDS2 for reversers, score approved drugs by reversal stability, then test them rank-wise in held-out PRISM/GDSC breast lines. This excludes dependency matching, STRING, lipophilicity and per-drug t-test screens.
Agente 2 · programmer
Escribió y ejecutó el código de cada grupo de trabajo. · 4 grupos entregados
Agente 3 · inspector
Revisó los resultados de cada grupo antes de darlos por buenos. · 4 grupos aprobados
Agente 4 · explorer
Buscó caminos que el equipo no había probado, más allá de lo pedido.
Agente 5 · reviewer
Independent review of claim f7e2f976-7995-4629-ae27-12c155ed1d94: TNBC L1000CDS2 reversal with 300 bootstrap TCGA signatures: controls reverse as often as real signatures (exploratory)
- Agentes de IA
- 5
- Llamadas al modelo
- 111
- Llamadas a herramientas
- 161
- Simulaciones exitosas
- 96/115
- Tiempo de CPU (todas las máquinas)
- 51 min 1 s
- Resultados
- 13
Literatura consultada (27)
- NTU-NPU System for Voice Privacy 2024 Challenge (2024)
- Discovery Opportunities with Gravitational Waves -- TASI 2024 Lecture Notes (2024)
- Concentration inequalities for leave-one-out cross validation (2022)
- Moments and Cumulants of The Two-Stage Mann-Whitney Statistic (2017)
- A doubly robust estimator for the Mann Whitney Wilcoxon Rank Sum Test when applied for causal inference in observational studies (2024)
- A two-sample test based on averaged Wilcoxon rank sums over interpoint distances (2024)
- Quasi-Perfect and Distance-Optimal Codes Sum-Rank Codes (2024)
- AI-guided deep visual proteomics reveals recurrence-associated morpho-molecular signatures within triple-negative breast cancers (2026)
- Screening Mammography Breast Cancer Detection (2023)
- Novel approach to locate region of interest in mammograms for Breast cancer (2018)
- A transcriptome-informed QSP model of metastatic triple-negative breast cancer identifies predictive biomarkers for PD-1 inhibition (2023)
- WNT signaling modulates PD-L1 expression in the stem cell compartment of triple-negative breast cancer (2019)
- Distinct immune microenvironment in HER2-low triple-negative breast cancer underlies inferior response to immunotherapy. (2026)
- Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2-Low Breast Cancer. (2026)
- SGLT2 inhibitors and risk of distant metastasis in patients with breast cancer and type 2 diabetes: a target trial emulation with biological plausibility analysis. (2026)
- Stromal biomarker-based framework for identifying pMMR/MSS and dMMR/MSI colorectal cancers with poor outcomes and limited benefit from immunotherapy. (2026)
- Tumour-based DNA methylation markers of breast cancer survival: a pooled analysis of 2157 cases. (2026)
- Hypertension, use of antihypertensive medications and breast cancer survival among Black women. (2026)
- Does propranolol have a role in cancer treatment? A systematic review of the epidemiological and clinical trial literature on beta-blockers. (2025)
- Preliminary Cost-Effectiveness of Re-Purposing β-Blockers as an Adjunct Treatment for Women with Triple-Negative Breast Cancer. (2025)
- Metabolic Modulation in Cancer Care: The Potential Role of Glucagon-Like Peptide-1 Receptor Agonists. (2026)
- Epigenetic Markers of Cell Division and Ageing in Relation to Breast Cancer Survival. (2026)
- Association of statin use with clinical outcomes in patients with triple‐negative breast cancer (2021)
- Commonly used medications and endometrial cancer survival: a population-based cohort study (2017)
- Post-diagnostic beta blocker use and breast cancer-specific mortality: a population-based cohort study (2022)
- Post-diagnostic statin use and breast cancer-specific mortality: a population-based cohort study (2023)
- Statin use in primary inflammatory breast cancer: a cohort study (2013)