Drug Repurposing Candidates for Triple-Negative Breast Cancer

Discover (after iteration 2) — find something NEW that iteration 2 did not establish: a pattern, formula, conjecture or effect that no published work reports. Start from what is still open: Re-run the 9-vs-9 screen with permutation p-values instead of Welch p-values (the mechanism study shows this restores FDR control) before trusting the q-value ranking; Quantify the basal-lineage confound for the 7 within-breast hits using the subtype table; Extend the sign-flip law to n_TNBC = 5–26 lines and test generality on PRISM/CTRP; Obtain a PRISM/CTRP subset with actual drug overlap (nutlin-3a shows replication is detectable when overlap exists) or wet-lab validate adavosertib in the 9-line panel; Preregister the mk-1775 selectivity claim with fixed line assignments and permutation-based statistics so it can be formally confirmed or rejected; Attach the DepMap Chronos matrix (researcher download) and run the pan-essential gene filter and docking triage, which never started. Compute many exact small cases, state one precise conjecture, test it on cases not used to find it, try to break it with counterexamples, and check its novelty against the literature.