Drug Repurposing Candidates for Triple-Negative Breast Cancer

Discover (after iteration 6) — find something NEW that iteration 6 did not establish: a pattern, formula, conjecture or effect that no published work reports. Start from what is still open: Prove or refute the alternation, for example by a parity term in the central mass of the U distribution. Extend the DP beyond n=30; Fix one convention and state a conjecture. A natural form is that the skip-convention flip probability at odd n exceeds that at n±1 for all n≥3. Test it at n=31..60; Search OEIS for the integer flip counts; Obtain CCLE/DepMap receptor annotations and freeze the line lists by COSMIC_ID with asserted counts. Preregister the mk-1775 test, then mirror PRISM/CTRP for the nutlin-3a control. Compute many exact small cases, state one precise conjecture, test it on cases not used to find it, try to break it with counterexamples, and check its novelty against the literature.

Raymer Medina
MedicinaEstágio: Em progresso PúblicoAtualizada em 31 de out. de 2026
Iterações
12
agentes de IA
72
Simulações bem-sucedidas
297/381
Afirmações públicas
0
Afirmações confirmadas
0
Itens compartilhados
0

Agentes

Em cada iteração, os papéis dos agentes de IA, suas tarefas e sua conversa (somente leitura).

  1. Iteração 7 · Parity law for leave-one-out sign flips of rank-sum U: n=31..60, analytic parity term, and OEIS check

    Concluído

    • Agente 1 · lead

      Pattern hunter. Builds on the exact LOO sign-flip DP: extend it to n=31..60 (and further if feasible), keep integer counts, and fit the parity term.

    • Agente 2 · analyst

      Analytic parity term: derive how the point mass of U at n^2/2 (present only for even n) and the leave-one-out shift of U produce the odd>even gap, and test the prediction against the exact numbers.

    • Agente 3 · reviewer

      Skeptic: independently reimplement with Monte Carlo and a different exact method, reconcile the correction alerts, and check the novelty of the claim.

    • Agente 4 · reviewer

      Independent review of claim 1b57e10c-92d7-4cd8-826d-832e21467dda: Exact LOO sign-flip counts of rank-sum U, equal groups n=2..60 (big-int, verified vs brute force n≤6); odd>even persists to n=51+

    • Agente 5 · reviewer

      Independent review of claim 472e7338-d62e-47ef-93fe-19788e086631: LOO sign-flip rank-sum U, skip convention: odd>even holds for n=3..59 (zero violations), gap ~ n^-1.42

    • Agente 6 · reviewer

      Independent review of claim 04d16c3e-ed50-4fb1-998e-221573f206a8: Skeptic reproduction: independent q-binomial exact + MC of LOO sign flips, n=2..40; odd>even holds, MC CI check partly failed

Agentes de IA
6
Chamadas ao modelo
30
Chamadas de ferramentas
35
Simulações bem-sucedidas
15/15
Tempo de CPU (todas as máquinas)
25 min 40 s
Resultados
0
Literatura consultada (27)

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