Drug Repurposing Candidates for Triple-Negative Breast Cancer

Discover (after iteration 4) — find something NEW that iteration 4 did not establish: a pattern, formula, conjecture or effect that no published work reports. Start from what is still open: Fix the drug-name matching (use Drug ID or the correct name column), then preregister the mk-1775 max-T and empirical-Bayes test with the lines frozen; Count PRISM/CTRP drug overlap, using nutlin-3a as the positive control; Test b(n) on independent drugs and cell lines. Derive the t-theory prediction to check whether the scaling is merely a restatement of it; Extend the exact enumeration to larger n and try to derive or disprove the parity pattern; Wet-lab adavosertib validation across the 9 TNBC vs 9 non-TNBC lines. Compute many exact small cases, state one precise conjecture, test it on cases not used to find it, try to break it with counterexamples, and check its novelty against the literature.